Reactome | Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX

Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX

Stable Identifier

R-HSA-163770

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The ACLY (ATP citrate synthase) gene, activated by binding of MLXIPL:MLX (ChREBP:MLX) to its promoter region, is transcribed and the resulting mRNA is translated to yield ACLY protein (Ma et al. 2005, 2006, 2007).

Literature References

PubMed ID	Title	Journal	Year
17148476	A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription Sham, YY, Towle, HC, Ma, L, Walters, KJ	Nucleic Acids Res.	2007
16885160	ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver Towle, HC, Ma, L, Robinson, LN	J. Biol. Chem.	2006
15664996	Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. Ma, L, Tsatsos, NG, Towle, HC	J Biol Chem	2005