Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX

Stable Identifier
R-HSA-163770
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The ACLY (ATP citrate synthase) gene, activated by binding of MLXIPL:MLX (ChREBP:MLX) to its promoter region, is transcribed and the resulting mRNA is translated to yield ACLY protein (Ma et al. 2005, 2006, 2007).
Literature References
PubMed ID Title Journal Year
17148476 A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription

Sham, YY, Towle, HC, Ma, L, Walters, KJ

Nucleic Acids Res. 2007
16885160 ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver

Towle, HC, Ma, L, Robinson, LN

J. Biol. Chem. 2006
15664996 Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes.

Ma, L, Tsatsos, NG, Towle, HC

J Biol Chem 2005
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