Reactome | (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate

Schema > Reaction > Entries

(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate Show undefined attributes

authored	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
catalystActivity	[CatalystActivity:162827] GPI mannosyltransferase activity of PIGV [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
dbId	162873
displayName	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-162710] Synthesis of glycosylphosphatidylinositol (GPI) - Homo sapiens
followingEvent	[Reaction:R-HSA-162821] mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Homo sapiens
input	[OtherEntity:R-ALL-8855663] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449229] DOLP-Man [lumenal side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:162795] PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol [LiteratureReference:162837] Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate
orthologousEvent	[Reaction:R-PFA-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Plasmodium falciparum [Reaction:R-SCE-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Saccharomyces cerevisiae [Reaction:R-SPO-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Schizosaccharomyces pombe [Reaction:R-DDI-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Dictyostelium discoideum [Reaction:R-CEL-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Caenorhabditis elegans [Reaction:R-DME-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Drosophila melanogaster [Reaction:R-GGA-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Gallus gallus [Reaction:R-XTR-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Xenopus tropicalis [Reaction:R-DRE-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Danio rerio [Reaction:R-SSC-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Sus scrofa [Reaction:R-BTA-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Bos taurus [Reaction:R-CFA-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Canis familiaris [Reaction:R-RNO-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Rattus norvegicus [Reaction:R-MMU-162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - Mus musculus
output	[SimpleEntity:R-ALL-162872] dolichyl phosphate [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-8855667] mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-162798] mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol - Homo sapiens [Reaction:R-HSA-162715] Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-162873
summation	[Summation:162685] In the seventh reaction of GPI synthesis, a second mannose r...
updateTrackers	[UpdateTracker:9783664] Update Tracker - [Reaction:162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - v56:[add_removeInput, add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9783664] Update Tracker - [Reaction:162873] (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate - v56:[add_removeInput, add_removeOutput]
(hasEvent)	[Pathway:R-HSA-162710] Synthesis of glycosylphosphatidylinositol (GPI)
(precedingEvent)	[Reaction:R-HSA-162821] mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate

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