(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate

Stable Identifier
R-HSA-162873
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the seventh reaction of GPI synthesis, a second mannose residue is added to the glycolipid on the lumenal face of the endoplasmic reticulum membrane. PIG-V was identified as the catylyst, or a component of the catalyst, of this reaction, on the basis of its ability to correct the metabolic defects of yeast and mammalian mutant cells arrested at this stage of the GPI synthetic process (Fabre et al. 2005; Kang et al. 2005).

Literature References
PubMed ID Title Journal Year
15720390 Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly

Fabre, AL, Orlean, P, Taron, CH

FEBS J 2005
15623507 PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol

Kang, JY, Hong, Y, Ashida, H, Shishioh, N, Murakami, Y, Morita, YS, Maeda, Y, Kinoshita, T

J Biol Chem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycolipid mannosyltransferase activity of PIGV [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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