(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate

Stable Identifier
Reaction [transition]
Homo sapiens
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In the seventh reaction of GPI synthesis, a second mannose residue is added to the glycolipid on the lumenal face of the endoplasmic reticulum membrane. PIG-V was identified as the catylyst, or a component of the catalyst, of this reaction, on the basis of its ability to correct the metabolic defects of yeast and mammalian mutant cells arrested at this stage of the GPI synthetic process (Fabre et al. 2005; Kang et al. 2005).

Literature References
PubMed ID Title Journal Year
15623507 PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol

Kinoshita, T, Murakami, Y, Kang, JY, Morita, YS, Ashida, H, Hong, Y, Maeda, Y, Shishioh, N

J Biol Chem 2005
15720390 Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly

Taron, CH, Orlean, P, Fabre, AL

FEBS J 2005
Catalyst Activity

glycolipid mannosyltransferase activity of PIGV [endoplasmic reticulum membrane]

Orthologous Events
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