Reactome | In the seventh reaction of GPI synthesis, a second mannose r...

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created	[InstanceEdit:162789] D'Eustachio, P, 2005-04-04 21:01:34
dbId	162685
displayName	In the seventh reaction of GPI synthesis, a second mannose r...
literatureReference	[LiteratureReference:162837] Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly [LiteratureReference:162795] PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol
modified	[InstanceEdit:164486] D'Eustachio, P, 2005-05-21 16:13:58
schemaClass	Summation
text	In the seventh reaction of GPI synthesis, a second mannose residue is added to the glycolipid on the lumenal face of the endoplasmic reticulum membrane. PIG-V was identified as the catylyst, or a component of the catalyst, of this reaction, on the basis of its ability to correct the metabolic defects of yeast and mammalian mutant cells arrested at this stage of the GPI synthetic process (Fabre et al. 2005; Kang et al. 2005).

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