NEU2 cleaves GM3 to form LacCer (cytosol)

Stable Identifier
R-HSA-1605723
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NEU2 cleaves GM3 to form LacCer (cytosol)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sialidase-2 (NEU2) hydrolyses Neu5Ac from GM3 in the cytosol (Monti et al. 1999).
Literature References
PubMed ID Title Journal Year
10191093 Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases

Borsani, G, Preti, A, Ballabio, A, Rossi, E, Monti, E

Genomics 1999
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Catalyst Activity

exo-alpha-sialidase activity of NEU2 [cytosol]

Physical Entity
NEU2 [cytosol] (Homo sapiens)
Activity
exo-alpha-sialidase activity (GO:0004308)
Orthologous Events
NEU2 cleaves GM3 to form LacCer (cytosol) (Bos taurus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Canis familiaris)
NEU2 cleaves GM3 to form LacCer (cytosol) (Danio rerio)
NEU2 cleaves GM3 to form LacCer (cytosol) (Gallus gallus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Mus musculus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Rattus norvegicus)
NEU2 cleaves GM3 to form LacCer (cytosol) (Sus scrofa)
NEU2 cleaves GM3 to form LacCer (cytosol) (Xenopus tropicalis)
Authored
Jassal, B  (2011-09-21)
Reviewed
Stephan, R  (2011-10-31)
Created
Jassal, B  (2011-09-21)
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