Reactome | Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2

Schema > Reaction > Entries

Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 Show undefined attributes

authored	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
catalystActivity	[CatalystActivity:1605789] beta-galactosidase activity of BGAL [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9840794] Stephan, Ralf, 2023-07-27
dbId	9840795
displayName	Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2
edited	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9840833] bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer - Homo sapiens
input	[Complex:R-HSA-9840793] GM2A:GA1 [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9842146] Role of beta-galactosidase and elastin binding protein in lysosomal and nonlysosomal complexes of patients with GM1-gangliosidosis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2
orthologousEvent	[Reaction:R-CEL-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Caenorhabditis elegans [Reaction:R-GGA-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Gallus gallus [Reaction:R-XTR-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Xenopus tropicalis [Reaction:R-SSC-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Sus scrofa [Reaction:R-BTA-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Bos taurus [Reaction:R-RNO-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Rattus norvegicus [Reaction:R-MMU-9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - Mus musculus
output	[SimpleEntity:R-ALL-1605637] Gal [lysosomal lumen] [Complex:R-HSA-9840792] GM2A:GA2 [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-1605717] GM2A binds and mobilizes ligands - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9840795
summation	[Summation:1605722] Ganglioside GA1 (asialo-GM1, ganglio-N-tetraosylceramide) is...
updateTrackers	[UpdateTracker:9853255] Update Tracker - [Reaction:9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - v87:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853255] Update Tracker - [Reaction:9840795] Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 - v87:[modifyText]
(precedingEvent)	[Reaction:R-HSA-9840833] bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer
(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism

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