Reactome | GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)

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GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) Show undefined attributes

catalystActivity	[CatalystActivity:159812] gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57
dbId	159826
displayName	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)
eventOf	[Pathway:R-HSA-159740] Gamma-carboxylation of protein precursors - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-159843] Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus - Homo sapiens [Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Homo sapiens
input	10 × [SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-159739] F2(25-622) [endoplasmic reticulum lumen] 10 × [SimpleEntity:R-ALL-6806362] MK4 [endoplasmic reticulum lumen] 10 × [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:159755] The vitamin K-dependent carboxylase [LiteratureReference:159753] Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid [LiteratureReference:159750] Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo [LiteratureReference:163831] Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate.
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) pro-prothrombin, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-prothrombin + 10 H2O + 10 vitamin K epoxide
orthologousEvent	[Reaction:R-MMU-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Mus musculus [Reaction:R-SSC-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Sus scrofa [Reaction:R-XTR-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Xenopus tropicalis [Reaction:R-BTA-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Bos taurus [Reaction:R-CFA-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Canis familiaris [Reaction:R-RNO-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-159800] 10xCbxE-F2(25-622) [endoplasmic reticulum lumen] 10 × [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] 10 × [SimpleEntity:R-ALL-6806366] MK4 epoxide [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Homo sapiens [Reaction:R-HSA-6806674] UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-159826
summation	[Summation:179122] GGCX (gamma glutamyl carboxylase) in the endoplasmic reticul...
updateTrackers	[UpdateTracker:9783869] Update Tracker - [Reaction:159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - v55:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783869] Update Tracker - [Reaction:159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - v55:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-159740] Gamma-carboxylation of protein precursors
(precedingEvent)	[BlackBoxEvent:R-HSA-159843] Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus [Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)