Reactome | Gamma-carboxylation of protein precursors

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Gamma-carboxylation of protein precursors Show undefined attributes

authored	[InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57
crossReference	[DatabaseIdentifier:12325386] BioModels Database:BIOMD0000000338 [DatabaseIdentifier:12325388] BioModels Database:BIOMD0000000340 [DatabaseIdentifier:12325398] BioModels Database:BIOMD0000000339
dbId	159740
displayName	Gamma-carboxylation of protein precursors
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-159854] Gamma-carboxylation, transport, and amino-terminal cleavage of proteins - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25728] peptidyl-glutamic acid carboxylation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Homo sapiens [Reaction:R-HSA-159761] GGCX gamma-carboxylates F7(21-466) (pro-factor VII) - Homo sapiens [Reaction:R-HSA-159819] GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) - Homo sapiens [Reaction:R-HSA-159826] GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) - Homo sapiens [Reaction:R-HSA-159795] GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) - Homo sapiens [Reaction:R-HSA-159752] GGCX gamma-carboxylates PROS1(25-676) (pro-protein S) - Homo sapiens [Reaction:R-HSA-163820] GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z) - Homo sapiens [Reaction:R-HSA-163810] GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6) - Homo sapiens [Reaction:R-HSA-6807214] GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin) - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:159755] The vitamin K-dependent carboxylase [LiteratureReference:159738] A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors [LiteratureReference:159753] Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid [LiteratureReference:159750] Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo [LiteratureReference:159719] Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors
modified	[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name	Gamma-carboxylation of protein precursors
orthologousEvent	[Pathway:R-XTR-159740] Gamma-carboxylation of protein precursors - Xenopus tropicalis [Pathway:R-SSC-159740] Gamma-carboxylation of protein precursors - Sus scrofa [Pathway:R-BTA-159740] Gamma-carboxylation of protein precursors - Bos taurus [Pathway:R-CFA-159740] Gamma-carboxylation of protein precursors - Canis familiaris [Pathway:R-RNO-159740] Gamma-carboxylation of protein precursors - Rattus norvegicus [Pathway:R-MMU-159740] Gamma-carboxylation of protein precursors - Mus musculus
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-159740
summation	[Summation:159814] Gamma-carboxylation of a cluster of glutamate residues near ...

Referrals

(hasEvent)

[Pathway:R-HSA-159854] Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

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