Reactome | GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)

Schema > Reaction > Entries

GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) Show undefined attributes

catalystActivity	[CatalystActivity:159812] gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:159817] D'Eustachio, P, 2005-03-17 16:24:57
dbId	159803
diseaseReaction	[FailedReaction:R-HSA-9673231] GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX) - Homo sapiens
displayName	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)
eventOf	[Pathway:R-HSA-159740] Gamma-carboxylation of protein precursors - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-159836] Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus - Homo sapiens [Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-159765] 3OHD110-F9(29-461) [endoplasmic reticulum lumen] 12 × [SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] 12 × [SimpleEntity:R-ALL-6806362] MK4 [endoplasmic reticulum lumen] 12 × [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:159755] The vitamin K-dependent carboxylase [LiteratureReference:159753] Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid [LiteratureReference:163831] Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. [LiteratureReference:159750] Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo [LiteratureReference:159725] Factor IX San Dimas. Substitution of glutamine for Arg-4 in the propeptide leads to incomplete gamma-carboxylation and altered phospholipid binding properties.
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) pro-factor IX, uncarboxylated + 12 CO2 + 12 O2 + 12 vitamin K hydroquinone -> pro-factor IX + 12 H2O + 12 vitamin K epoxide
orthologousEvent	[Reaction:R-MMU-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Mus musculus [Reaction:R-RNO-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Rattus norvegicus [Reaction:R-CFA-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Canis familiaris [Reaction:R-BTA-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Bos taurus [Reaction:R-XTR-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Xenopus tropicalis [Reaction:R-SSC-159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - Sus scrofa
output	[EntityWithAccessionedSequence:R-HSA-159866] 12xCbxE-3D-F9(29-461) [endoplasmic reticulum lumen] 12 × [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] 12 × [SimpleEntity:R-ALL-6806366] MK4 epoxide [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone) - Homo sapiens [Reaction:R-HSA-6806674] UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone) - Homo sapiens
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-159803
summation	[Summation:179103] GGCX (gamma glutamyl carboxylase) in the endoplasmic reticul...
updateTrackers	[UpdateTracker:9783859] Update Tracker - [Reaction:159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - v55:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783859] Update Tracker - [Reaction:159803] GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) - v55:[add_removeInput, add_removeOutput, modifyText]
(normalReaction)	[FailedReaction:R-HSA-9673231] GGCX does not gamma-carboxylate 3D-F9(29-461) (pro-factor IX)
(hasEvent)	[Pathway:R-HSA-159740] Gamma-carboxylation of protein precursors
(precedingEvent)	[BlackBoxEvent:R-HSA-159836] Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus [Reaction:R-HSA-159790] VKORC1 reduces vitamin K epoxide to MK4 (vitamin K hydroquinone)

Cite Us!