GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates twelve glutamate residues on 3D-F9(29-461) (pro-factor IX). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995; Ware et al. 1989).
Furie, B, Stafford, DW, Diuguid, DL, Liebman, HA, Rabiet, MJ, Ware, J, Kasper, CK, Furie, BC
Furie, B, Bouchard, BA, Furie, BC
Berkner, KL
Stafford, DW, Wright, DJ, Stevens, RD, Morris, DP
Stenina, O, Pudota, BN, Berkner, KL, McNally, BA, Hommema, EL
gamma-glutamyl carboxylase activity of GGCX [endoplasmic reticulum membrane]
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