Reactome | benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A

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benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A Show undefined attributes

catalystActivity	[CatalystActivity:159547] glycine N-benzoyltransferase activity of GLYAT-like proteins [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:159568] Jassal, B, 2005-03-11 11:56:39
crossReference	[DatabaseIdentifier:12668234] RHEA:18494
dbId	159566
displayName	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A
eventOf	[Pathway:R-HSA-177135] Conjugation of benzoate with glycine - Homo sapiens
input	[SimpleEntity:R-ALL-159447] BEZ-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:159562] Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man [LiteratureReference:177161] Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A Benzoyl-CoA forms an amide bond with glycine
orthologousEvent	[Reaction:R-CEL-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Caenorhabditis elegans [Reaction:R-GGA-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Gallus gallus [Reaction:R-XTR-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Xenopus tropicalis [Reaction:R-SSC-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Sus scrofa [Reaction:R-BTA-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Bos taurus [Reaction:R-CFA-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Canis familiaris [Reaction:R-RNO-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Rattus norvegicus [Reaction:R-MMU-159566] benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A - Mus musculus
output	[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-159564] HIPA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-159443] benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate - Homo sapiens
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-159566
summation	[Summation:177134] Benzoyl CoA and glycine react to form benzoyl glycine (hippu...

Referrals

(hasEvent)

[Pathway:R-HSA-177135] Conjugation of benzoate with glycine

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