Reactome | benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A

benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A

Stable Identifier

R-HSA-159566

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Benzoyl-CoA forms an amide bond with glycine

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase II - Conjugation of compounds (Homo sapiens)
    - Amino Acid conjugation (Homo sapiens)
      - Conjugation of carboxylic acids (Homo sapiens)
        
        Conjugation of benzoate with glycine (Homo sapiens)
        
        benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A (Homo sapiens)

General

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benzoyl-CoA + glycine => benzoyl glycine (hippuric acid) + Coenzyme A

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Benzoyl CoA and glycine react to form benzoyl glycine (hippuric acid) and Coenzyme A (Mawal and Qureshi 1994).

Literature References

PubMed ID	Title	Journal	Year
7802672	Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver Qureshi, IA, Mawal, YR	Biochem Biophys Res Commun	1994
931988	Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man Strong, JM, Mieyal, JJ, Lucas, SV, Webster, LT, Siddiqui, UA	J Biol Chem	1976