Reactome | crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)

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crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) Show undefined attributes

authored	[InstanceEdit:158778] D'Eustachio, P, 2005-02-08 21:36:34
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158778] D'Eustachio, P, 2005-02-08 21:36:34
dbId	158781
displayName	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-75205] Dissolution of Fibrin Clot - Homo sapiens
followingEvent	[Reaction:R-HSA-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Homo sapiens [Reaction:R-HSA-158784] crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen - Homo sapiens
input	[OtherEntity:R-ALL-157771] fibrin multimer, crosslinked [extracellular region] [EntityWithAccessionedSequence:R-HSA-158754] PLAT(36-562) [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:158755] Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. [LiteratureReference:158782] Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin [LiteratureReference:158751] Tissue plasminogen activator: peptide analyses confirm an indirectly derived amino acid sequence, identify the active site serine residue, establish glycosylation sites, and localize variant differences
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain)
orthologousEvent	[Reaction:R-GGA-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Gallus gallus [Reaction:R-XTR-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Xenopus tropicalis [Reaction:R-DRE-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Danio rerio [Reaction:R-SSC-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Sus scrofa [Reaction:R-BTA-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Bos taurus [Reaction:R-CFA-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Canis familiaris [Reaction:R-RNO-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Rattus norvegicus [Reaction:R-MMU-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Mus musculus
output	[Complex:R-HSA-158764] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-140851] fibrin multimer -> fibrin multimer, crosslinked + NH4+ - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-158781
summation	[Summation:158779] The first step in the dissolution of a fibrin clot is the as...

Referrals

(hasEvent)

[Pathway:R-HSA-75205] Dissolution of Fibrin Clot

(precedingEvent)

[Reaction:R-HSA-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1
[Reaction:R-HSA-158784] crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen

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