Reactome | fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1

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fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 Show undefined attributes

authored	[InstanceEdit:158796] D'Eustachio, P, 2005-02-08 22:51:14
catalystActivity	[CatalystActivity:158919] serine-type endopeptidase inhibitor activity of SERPINE1-like proteins [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:158796] D'Eustachio, P, 2005-02-08 22:51:14
dbId	158795
displayName	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-75205] Dissolution of Fibrin Clot - Homo sapiens
input	[Complex:R-HSA-158764] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) [extracellular region] [EntityWithAccessionedSequence:R-HSA-158797] SERPINE1 [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:158798] Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA.
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1
orthologousEvent	[Reaction:R-XTR-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Xenopus tropicalis [Reaction:R-DRE-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Danio rerio [Reaction:R-SSC-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Sus scrofa [Reaction:R-BTA-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Bos taurus [Reaction:R-CFA-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Canis familiaris [Reaction:R-RNO-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Rattus norvegicus [Reaction:R-MMU-158795] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 - Mus musculus
output	[Complex:R-HSA-158791] fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1 [extracellular region]
precedingEvent	[Reaction:R-HSA-158781] crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-158795
summation	[Summation:158799] Plasminogen activator inhibitor 1, a serpin, binds to fibrin...

Referrals

(hasEvent)

[Pathway:R-HSA-75205] Dissolution of Fibrin Clot

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