Reactome | NICD1 [nucleoplasm]

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-9824247] RBPJ:NICD1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-9667653] NICD1:NBEA [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1912396] NICD1 binds HIF1A - Homo sapiens [Reaction:R-NUL-2064264] NICD1 displaces NCOR co-repressor complex from CSL - Cercopithecus aethiops [Reaction:R-HSA-1912388] NICD1 displaces co-repressor complex from RBPJ (CSL) - Homo sapiens [Reaction:R-HSA-9667657] NBEA binds NICD1 - Homo sapiens [Reaction:R-HSA-9762102] NICD1 binds the NFE2L2 promoter - Homo sapiens [Reaction:R-HSA-9824266] LEF1:CTNNB1, NICD1 (NOTCH1) and TBX6 bind the HES7 gene in presomitic mesoderm - Homo sapiens
created	[InstanceEdit:157631] Jassal, B, 2005-01-04 16:01:41
dbId	157939
displayName	NICD1 [nucleoplasm]
endCoordinate	2555
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-157939] NICD1 [nucleoplasm] - Mus musculus [GenomeEncodedEntity:R-RNO-157939] Ghost homologue of NICD1 [nucleoplasm] - Rattus norvegicus [GenomeEncodedEntity:R-CFA-157939] Ghost homologue of NICD1 [nucleoplasm] - Canis familiaris [GenomeEncodedEntity:R-BTA-157939] Ghost homologue of NICD1 [nucleoplasm] - Bos taurus [GenomeEncodedEntity:R-SSC-157939] Ghost homologue of NICD1 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-157939] NICD1 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-157939] NICD1 [nucleoplasm] - Gallus gallus [GenomeEncodedEntity:R-DME-157939] Ghost homologue of NICD1 [nucleoplasm] - Drosophila melanogaster [GenomeEncodedEntity:R-CEL-157939] Ghost homologue of NICD1 [nucleoplasm] - Caenorhabditis elegans
memberOf	[DefinedSet:R-HSA-212420] NICD [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3325515] Orlic-Milacic, M, 2013-05-09
name	NICD1 NOTCH1(1754-2555) NICD 1 fragment NOTCH1 intracellular domain N1ICD
producedByEvent	[Reaction:R-HSA-157926] NICD1 traffics to nucleus - Homo sapiens
referenceEntity	[ReferenceGeneProduct:60520] UniProt:P46531 NOTCH1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-157939
startCoordinate	1754

(normalEntity)	[EntityFunctionalStatus:2775826] gain_of_function of NICD1 PEST Domain Mutants [nucleoplasm]
(input)	[Reaction:R-HSA-9824266] LEF1:CTNNB1, NICD1 (NOTCH1) and TBX6 bind the HES7 gene in presomitic mesoderm [Reaction:R-HSA-9667657] NBEA binds NICD1 [Reaction:R-HSA-1912396] NICD1 binds HIF1A [Reaction:R-HSA-9762102] NICD1 binds the NFE2L2 promoter [Reaction:R-NUL-2064264] NICD1 displaces NCOR co-repressor complex from CSL [Reaction:R-HSA-1912388] NICD1 displaces co-repressor complex from RBPJ (CSL)
(hasComponent)	[Complex:R-HSA-9824247] RBPJ:NICD1 [nucleoplasm] [Complex:R-HSA-9667653] NICD1:NBEA [nucleoplasm] [Complex:R-HSA-1911469] NICD1:HIF1A [nucleoplasm] [Complex:R-HSA-9762079] NFE2L2 gene:NICD1 [nucleoplasm] [Complex:R-HSA-1604460] NICD1:RBPJ:SNW1 [nucleoplasm]
(hasMember)	[DefinedSet:R-HSA-212420] NICD [nucleoplasm]
(activeUnit)	[PositiveGeneExpressionRegulation:9762090] Positive gene expression regulation by 'NFE2L2 gene:NICD1 [nucleoplasm]'
(output)	[Reaction:R-HSA-157926] NICD1 traffics to nucleus

NICD1 [nucleoplasm] Show undefined attributes

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