Reactome | GTP-binding activates eEF2

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GTP-binding activates eEF2 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:156906] Gopinathrao, G, 2004-12-14 18:38:21
dbId	156930
displayName	GTP-binding activates eEF2
eventOf	[Pathway:R-HSA-156902] Peptide chain elongation - Homo sapiens
followingEvent	[Reaction:R-HSA-156915] Translocation of ribosome by 3 bases in the 3' direction - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-156901] EEF2 [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8984211] GTP binding to elongation factor eEF-2 unmasks a tryptophan residue required for biological activity
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GTP-binding activates eEF2
orthologousEvent	[Reaction:R-PFA-156930] GTP-binding activates eEF2 - Plasmodium falciparum [Reaction:R-SCE-156930] GTP-binding activates eEF2 - Saccharomyces cerevisiae [Reaction:R-SPO-156930] GTP-binding activates eEF2 - Schizosaccharomyces pombe [Reaction:R-DDI-156930] GTP-binding activates eEF2 - Dictyostelium discoideum [Reaction:R-CEL-156930] GTP-binding activates eEF2 - Caenorhabditis elegans [Reaction:R-DME-156930] GTP-binding activates eEF2 - Drosophila melanogaster [Reaction:R-GGA-156930] GTP-binding activates eEF2 - Gallus gallus [Reaction:R-XTR-156930] GTP-binding activates eEF2 - Xenopus tropicalis [Reaction:R-DRE-156930] GTP-binding activates eEF2 - Danio rerio [Reaction:R-SSC-156930] GTP-binding activates eEF2 - Sus scrofa [Reaction:R-BTA-156930] GTP-binding activates eEF2 - Bos taurus [Reaction:R-CFA-156930] GTP-binding activates eEF2 - Canis familiaris [Reaction:R-RNO-156930] GTP-binding activates eEF2 - Rattus norvegicus [Reaction:R-MMU-156930] GTP-binding activates eEF2 - Mus musculus
output	[Complex:R-HSA-156916] eEF2:GTP [cytosol]
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-156930
summation	[Summation:178830] At the beginning of this reaction, 1 molecule of 'eEF2', and...
updateTrackers	[UpdateTracker:9781276] Update Tracker - [Reaction:156930] GTP-binding activates eEF2 - v61:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9781276] Update Tracker - [Reaction:156930] GTP-binding activates eEF2 - v61:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-156915] Translocation of ribosome by 3 bases in the 3' direction
(hasEvent)	[Pathway:R-HSA-156902] Peptide chain elongation