Reactome | Collagen type VI degradation by MMP2,9,11

Collagen type VI degradation by MMP2,9,11

Stable Identifier

R-HSA-1564112

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Collagen type VI degradation by MMP2,9,11

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Type VI collagen aggregates into distinctive microfibrils known as beaded filaments that form an independent microfibrillar network in virtually all connective tissues except for bone (von der Mark et al. 1984). It plays a role in the maintenance of tissue integrity since it participates in both cell-matrix and matrix-matrix interactions, interacting with many other ECM proteins including fibronectin (Chang et al. 1997), type IV collagen (Kuo et al. 1997), type II collagen, decorin and biglycan (Bidanset et al. 1992). Collagen type VI has been described as a connecting protein (Gelse et al. 2003).

Collagen type VI is resistant to digestion by many MMPs but is cleaved by MMP2 (Myint et al. 1996, Veidal et al. 2011), MMP9 (Veidal et al. 2011) and MMP11 (Motrescu et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18622425	Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions Motrescu, ER, Blaise, S, Etique, N, Messaddeq, N, Chenard, MP, Stoll, I, Tomasetto, C, Rio, MC	Oncogene	2008
21935455	MMP mediated degradation of type VI collagen is highly associated with liver fibrosis--identification and validation of a novel biochemical marker assay Veidal, SS, Karsdal, MA, Vassiliadis, E, Nawrocki, A, Larsen, MR, Nguyen, QH, Hägglund, P, Luo, Y, Zheng, Q, Vainer, B, Leeming, DJ	PLoS One	2011