Reactome | PIK3CA H1047R [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PIK3CA H1047R [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
crossReference	[DatabaseIdentifier:12021366] Mondo:0005505 [DatabaseIdentifier:2362393] COSMIC:COSV55873195 [DatabaseIdentifier:2395921] COSMIC:COSM29325
dbId	1500716
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:1500687] stomach cancer [Disease:1247632] glioblastoma [Disease:1500575] ovarian cancer [Disease:2317358] endometrial cancer [Disease:2328198] pancreatic cancer [Disease:1500699] lung cancer [Disease:2327997] pharynx cancer [Disease:1493885] bladder carcinoma [Disease:1614289] melanoma [Disease:2317371] ovarian endometrioid neoplasm [Disease:2328196] pituitary adenoma [Disease:1655470] thyroid cancer [Disease:1996312] brain glioma [Disease:2318519] medulloblastoma [Disease:2318576] oral cavity cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:2328081] non-Hodgkin lymphoma [Disease:1655499] prostate cancer [Disease:2327993] hepatocellular carcinoma [Disease:1614672] cervical cancer [Disease:2362392] brain meningioma [Disease:2362396] peripheral primitive neuroectodermal tumor [Disease:2362395] dysembryoplastic neuroepithelial tumor [Disease:2327996] gallbladder carcinoma [Disease:2396014] seborrheic keratosis
displayName	PIK3CA H1047R [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:1500690] L-histidine 1047 replaced with L-arginine
inDisease	true
literatureReference	[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells [LiteratureReference:2399642] Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases
maxDepth	1
memberOf	[CandidateSet:R-HSA-2399596] PIK3CA kinase domain mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA H1047R PIK3CA His1047Arg
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1500716
startCoordinate	1
summation	[Summation:2399644] Substitution of histidine residue with arginine at position ...
updateTrackers	[UpdateTracker:9887911] Update Tracker - [EntityWithAccessionedSequence:1500716] PIK3CA H1047R [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9887911] Update Tracker - [EntityWithAccessionedSequence:1500716] PIK3CA H1047R [cytosol] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2399596] PIK3CA kinase domain mutants [cytosol]

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