Reactome | PIK3CA E542K [cytosol]

Schema > EntityWithAccessionedSequence > Entries

PIK3CA E542K [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
crossReference	[DatabaseIdentifier:12021363] Mondo:0005524 [DatabaseIdentifier:2327988] COSMIC:COSV55873227 [DatabaseIdentifier:2327992] COSMIC:COSM29329
dbId	1500701
disease	[Disease:1248674] large intestine cancer [Disease:1500689] cancer [Disease:1493885] bladder carcinoma [Disease:1500576] breast cancer [Disease:2327998] esophageal carcinoma [Disease:1500687] stomach cancer [Disease:2317358] endometrial cancer [Disease:2328000] gum cancer [Disease:2327994] penis carcinoma [Disease:1500699] lung cancer [Disease:1614672] cervical cancer [Disease:1655470] thyroid cancer [Disease:2317371] ovarian endometrioid neoplasm [Disease:2327990] pituitary cancer [Disease:2317476] acute lymphocytic leukemia [Disease:1247632] glioblastoma [Disease:2327987] sweat gland carcinoma [Disease:2327993] hepatocellular carcinoma [Disease:1996312] brain glioma [Disease:1500575] ovarian cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:2327997] pharynx cancer [Disease:2318576] oral cavity cancer [Disease:1655484] kidney cancer [Disease:2327989] bile duct carcinoma [Disease:2327996] gallbladder carcinoma [Disease:2328001] skin squamous cell carcinoma [Disease:2396014] seborrheic keratosis
displayName	PIK3CA E542K [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:1500700] L-glutamic acid 542 replaced with L-lysine
inDisease	true
literatureReference	[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
maxDepth	1
memberOf	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens
modified	[InstanceEdit:5696640] Matthews, Lisa, 2015-05-29
name	PIK3CA E542K PIK3CA Glu542Lys
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1500701
startCoordinate	1
summation	[Summation:2399583] Substitution of glutamic acid residue at position 542 of PIK...
updateTrackers	[UpdateTracker:9888232] Update Tracker - [EntityWithAccessionedSequence:1500701] PIK3CA E542K [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9888232] Update Tracker - [EntityWithAccessionedSequence:1500701] PIK3CA E542K [cytosol] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]