Reactome | Substitution of glutamic acid residue at position 542 of PIK...

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created	[InstanceEdit:2399582] Orlic-Milacic, M, 2012-07-11
dbId	2399583
displayName	Substitution of glutamic acid residue at position 542 of PIK...
literatureReference	[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells
modified	[InstanceEdit:2399629] Orlic-Milacic, M, 2012-07-11
schemaClass	Summation
text	Substitution of glutamic acid residue at position 542 of PIK3CA with lysine disrupts inhibitory interaction between the helical domain of PIK3CA and the nSH2 domain of PIK3R1. The PI3K complex containing PIK3CA E542K mutant is constitutively active (Miled et al. 2007, Horn et al. 2008).

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