Reactome | PIK3CA Q546P [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1500696] Orlic-Milacic, Marija, 2011-08-19
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575 [DatabaseIdentifier:2362371] COSMIC:COSV55875400
dbId	1500695
disease	[Disease:1248674] large intestine cancer [Disease:1500689] cancer [Disease:1996312] brain glioma [Disease:1500576] breast cancer [Disease:1500575] ovarian cancer [Disease:2317358] endometrial cancer
displayName	PIK3CA Q546P [cytosol]
endCoordinate	1068
hasModifiedResidue	[ReplacedResidue:1500717] L-glutamine 546 replaced with L-proline
inDisease	true
literatureReference	[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
maxDepth	1
modified	[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	PIK3CA Q546P PIK3CA Gln546Pro
referenceEntity	[ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1500695
startCoordinate	1
summation	[Summation:2399621] Based on structural and functional studies of PIK3CA Q546K m...
updateTrackers	[UpdateTracker:9887609] Update Tracker - [EntityWithAccessionedSequence:1500695] PIK3CA Q546P [cytosol] - v46:[modifyName]

(updatedInstance)	[UpdateTracker:9887609] Update Tracker - [EntityWithAccessionedSequence:1500695] PIK3CA Q546P [cytosol] - v46:[modifyName]
(hasCandidate)	[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]

Cite Us!