Ascorbate can reduce the BH3 radical back to BH4

Stable Identifier
R-HSA-1497855
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Ascorbate can reduce the BH3 radical back to BH4
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Ascorbate (AscH-) can reduce the BH3 radical back to BH4, thereby maintaining BH4 levels (Baker et al. 2001, Patel et al. 2002, Kuzkaya et al. 2003).

Literature References
PubMed ID Title Journal Year
11827745 Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate

Everett, SA, Stratford, MR, Patel, KB, Wardman, P

Free Radic Biol Med 2002
11243424 Effect of vitamin C on the availability of tetrahydrobiopterin in human endothelial cells

Milstien, S, Katusic, ZS, Baker, TA

J Cardiovasc Pharmacol 2001
12692136 Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase

Harrison, DG, Kuzkaya, N, Dikalov, S, Weissmann, N

J Biol Chem 2003
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Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)
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