Salvage - BH2 is reduced to BH4 by DHFR

Stable Identifier
R-HSA-1497794
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Salvage - BH2 is reduced to BH4 by DHFR
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In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).

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Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
dihydrofolate reductase activity of DHFR dimer [cytosol]
Physical Entity
DHFR dimer [cytosol]
Activity
dihydrofolate reductase activity (0004146)
Inferred From
Salvage - BH2 is reduced to BH4 by Dhfr (Mus musculus)
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)
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