Salvage - BH2 is reduced to BH4 by DHFR

Stable Identifier
R-HSA-1497794
Type
Reaction
Species
Homo sapiens
Compartment
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In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).

Participants
Participates
Catalyst Activity

dihydrofolate reductase activity of DHFR dimer [cytosol]

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