Salvage - BH2 is reduced to BH4 by DHFR

Stable Identifier
R-HSA-1497794
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Salvage - BH2 is reduced to BH4 by DHFR
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
dihydrofolate reductase activity of DHFR dimer [cytosol]
Physical Entity
DHFR dimer [cytosol]
Activity
dihydrofolate reductase activity (0004146)
Inferred From
Salvage - BH2 is reduced to BH4 by Dhfr (Mus musculus)
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-08-17)