Reactome | 2-acyl LPC is hydrolyzed to GPCho by PLA2[8]

Schema > Reaction > Entries

2-acyl LPC is hydrolyzed to GPCho by PLA2[8] Show undefined attributes

authored	[InstanceEdit:1602345] Williams, MG, 2011-09-14
catalystActivity	[CatalystActivity:1524022] phosphatidylcholine lysophospholipase A1 activity of PLA2(8) [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:1482525] Williams, MG, 2011-08-12
dbId	1482612
displayName	2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
edited	[InstanceEdit:1482514] Williams, MG, 2011-08-12
eventOf	[Pathway:R-HSA-1483115] Hydrolysis of LPC - Homo sapiens
followingEvent	[Reaction:R-HSA-1483116] GPCho is hydrolyzed to Cho and G3P by GPCPD1 - Homo sapiens
input	[SimpleEntity:R-ALL-975614] 2-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482693] The identification of a phospholipase B precursor in human neutrophils [LiteratureReference:1482664] Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms [LiteratureReference:1482518] Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2 [LiteratureReference:1482631] Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) [LiteratureReference:1482624] Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	2-acyl LPC is hydrolyzed to GPCho by PLA2[8]
orthologousEvent	[Reaction:R-SCE-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Saccharomyces cerevisiae [Reaction:R-SPO-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Schizosaccharomyces pombe [Reaction:R-DDI-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Dictyostelium discoideum [Reaction:R-GGA-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Gallus gallus [Reaction:R-XTR-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Xenopus tropicalis [Reaction:R-DRE-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Danio rerio [Reaction:R-SSC-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Sus scrofa [Reaction:R-BTA-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Bos taurus [Reaction:R-CFA-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Canis familiaris [Reaction:R-RNO-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Rattus norvegicus [Reaction:R-MMU-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Mus musculus
output	[SimpleEntity:R-ALL-1498750] GPCho [cytosol] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens [Reaction:R-HSA-1482827] PC is hydrolyzed to 2-acyl LPC by PLA2G4C - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1482612
summation	[Summation:1482535] At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosp...

Referrals

(hasEvent)	[Pathway:R-HSA-1483115] Hydrolysis of LPC
(precedingEvent)	[Reaction:R-HSA-1483116] GPCho is hydrolyzed to Cho and G3P by GPCPD1

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