2-acyl LPC is hydrolyzed to GPCho by PLA2[8]

Stable Identifier
Reaction [transition]
Homo sapiens
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At the endoplasmic reticulum (ER) membrane, 2-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.
Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC

J Biol Chem 2010
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Waku, K, Nakanishi, H, Yamashita, A, Kawagishi, N, Kamata, R, Sugiura, T, Suzuki, H

J Biochem 2005
19019078 The identification of a phospholipase B precursor in human neutrophils

Venge, P, Zhao, L, Larsson, A, Xu, S

FEBS J 2009
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Waku, K, Tanaka, K, Kumazawa, T, Yamashita, A, Kamata, R, Sugiura, T, Koga, H, Suzuki, N

Biochim Biophys Acta 2009
8083230 Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2

Pickard, RT, Sharp, JD, Brems, DN, Miller, JR, Manetta, JV, Strifler, BA, Roberts, EF, Kovacevic, S, Varshavsky, AD, Chiou, XG

J Biol Chem 1994
Catalyst Activity

lysophospholipase activity of PLA2(8) [cytosol]

Orthologous Events
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