Collagen type III degradation by MMP1,8,9,13

Stable Identifier
Reaction [transition]
Homo sapiens
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MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996, Mitchell et al. 1996), called collagenases I, II and III respectively, are all able to cleave the intrahelical bonds of collagen type III, cleaving between amino acids Gly948 and Ile949 of the Uniprot canonical sequence. MMP9 (Bigg et al. Veidal et al. 2010) and MMP10 (Stromelysin-2) are able to degrade collagen type III (Nicholson et al. 1989).

Literature References
PubMed ID Title Journal Year
3038863 The collagen substrate specificity of human neutrophil collagenase

Hasty, KA, Jeffrey, JJ, Hibbs, MS, Welgus, HG

J Biol Chem 1987
15257288 Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis

Chung, L, Dinakarpandian, D, Yoshida, N, Lauer-Fields, JL, Fields, GB, Visse, R, Nagase, H

EMBO J 2004
6270089 The collagen substrate specificity of human skin fibroblast collagenase

Welgus, HG, Jeffrey, JJ, Eisen, AZ

J Biol Chem 1981
8999957 Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules

Ohuchi, E, Imai, K, Fujii, Y, Sato, H, Seiki, M, Okada, Y

J Biol Chem 1997
8576151 Biochemical characterization of human collagenase-3

Knäuper, V, López-Otin, C, Smith, B, Knight, G, Murphy, G

J Biol Chem 1996
Catalyst Activity

metalloendopeptidase activity of MMP1,8,9,13 [extracellular region]

Orthologous Events
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