Reactome | Collagen type III degradation by MMP1,8,9,13

Collagen type III degradation by MMP1,8,9,13

Stable Identifier

R-HSA-1474213

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Collagen type III degradation by MMP1,8,9,13

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MMP1 (Welgus et al. 1981), MMP8 (Hasty et al. 1987), and MMP13 (Knauper et al. 1996, Mitchell et al. 1996), called collagenases I, II and III respectively, are all able to cleave the intrahelical bonds of collagen type III, cleaving between amino acids Gly948 and Ile949 of the Uniprot canonical sequence. MMP9 (Bigg et al. Veidal et al. 2010) and MMP10 (Stromelysin-2) are able to degrade collagen type III (Nicholson et al. 1989).

Literature References

PubMed ID	Title	Journal	Year
15257288	Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis Chung, L, Dinakarpandian, D, Yoshida, N, Lauer-Fields, JL, Fields, GB, Visse, R, Nagase, H	EMBO J	2004
3038863	The collagen substrate specificity of human neutrophil collagenase Hasty, KA, Jeffrey, JJ, Hibbs, MS, Welgus, HG	J Biol Chem	1987
6270089	The collagen substrate specificity of human skin fibroblast collagenase Welgus, HG, Jeffrey, JJ, Eisen, AZ	J Biol Chem	1981
8999957	Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules Ohuchi, E, Imai, K, Fujii, Y, Sato, H, Seiki, M, Okada, Y	J Biol Chem	1997
8576151	Biochemical characterization of human collagenase-3 Knäuper, V, López-Otin, C, Smith, B, Knight, G, Murphy, G	J Biol Chem	1996