Reactome | HNP1-4 are released into phagocytic vacuoles

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HNP1-4 are released into phagocytic vacuoles Show undefined attributes

authored	[InstanceEdit:1254178] Jupe, S, 2011-04-28
category	transition
compartment	[Compartment:1470028] azurophil granule lumen [Compartment:984] extracellular region
created	[InstanceEdit:1461974] Jupe, S, 2011-07-27
dbId	1462041
displayName	HNP1-4 are released into phagocytic vacuoles
edited	[InstanceEdit:1461956] Jupe, S, 2011-07-27
eventOf	[Pathway:R-HSA-1462054] Alpha-defensins - Homo sapiens
followingEvent	[Reaction:R-HSA-1471354] HNP1-3 bind gp120 - Homo sapiens [Reaction:R-HSA-1972385] ADP-Ribosylation of HNP-1 - Homo sapiens [Reaction:R-HSA-1471314] HNP1-3 bind CD4 - Homo sapiens [Reaction:R-HSA-1462014] Alpha-defensins form biologically active dimers - Homo sapiens
input	[CandidateSet:R-HSA-1470049] Defensins alpha 1-4 [azurophil granule lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1472823] Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines [LiteratureReference:1472841] Defensins: endogenous antibiotic peptides from human leukocytes [LiteratureReference:1472835] Processing and targeting of granule proteins in human neutrophils
maxDepth	1
modified	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
name	HNP1-4 are released into phagocytic vacuoles
orthologousEvent	[Reaction:R-MMU-1462041] HNP1-4 are released into phagocytic vacuoles - Mus musculus [Reaction:R-RNO-1462041] HNP1-4 are released into phagocytic vacuoles - Rattus norvegicus
output	[CandidateSet:R-HSA-1471313] Defensins alpha 1-4 [extracellular region]
precedingEvent	[Reaction:R-HSA-1462003] HNP1-4 are stored in primary neutrophil granules - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1966942] McDermott, AM, 2011-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1462041
summation	[Summation:1472838] Human neutrophils contain thousands of cytoplasmic granules....

Referrals

(hasEvent)	[Pathway:R-HSA-1462054] Alpha-defensins
(precedingEvent)	[Reaction:R-HSA-1471354] HNP1-3 bind gp120 [Reaction:R-HSA-1972385] ADP-Ribosylation of HNP-1 [Reaction:R-HSA-1471314] HNP1-3 bind CD4 [Reaction:R-HSA-1462014] Alpha-defensins form biologically active dimers

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