HNP1-4 are released into phagocytic vacuoles

Stable Identifier
R-HSA-1462041
Type
Reaction [transition]
Species
Homo sapiens
Compartment
azurophil granule lumen, extracellular region
ReviewStatus
5/5
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HNP1-4 are released into phagocytic vacuoles
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Human neutrophils contain thousands of cytoplasmic granules. These membrane-bound organelles act as storage compartments destined for secretion or in the case of azurophil granules, destined for fusion with phagosomes. A small amount of defensin, but perhaps not enough for antimicrobial activity, may be released extracellularly by neutrophils (Ganz 1987).
Literature References
PubMed ID Title Journal Year
1302183 Defensins: endogenous antibiotic peptides from human leukocytes

Ganz, T, Lehrer, RI

Ciba Found Symp 1992
10618521 Processing and targeting of granule proteins in human neutrophils

Gullberg, U, Lindmark, A, Bülow, E, Olsson, I, Bengtsson, N, Garwicz, D

J Immunol Methods 1999
8329717 Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines

Ganz, T, Valore, EV, Oren, A, Liu, L

Blood 1993
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Orthologous Events
HNP1-4 are released into phagocytic vacuoles (Mus musculus)
HNP1-4 are released into phagocytic vacuoles (Rattus norvegicus)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)
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