HNP1-4 are released into phagocytic vacuoles

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R-HSA-1462041
Type
Reaction
Species
Homo sapiens
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Human neutrophils contain thousands of cytoplasmic granules. These membrane-bound organelles act as storage compartments destined for secretion or in the case of azurophil granules, destined for fusion with phagosomes. A small amount of defensin, but perhaps not enough for antimicrobial activity, may be released extracellularly by neutrophils (Ganz 1987).

Literature References
PubMed ID Title Journal Year
1302183 Defensins: endogenous antibiotic peptides from human leukocytes

Ganz, T, Lehrer, RI

Ciba Found Symp 1992
10618521 Processing and targeting of granule proteins in human neutrophils

Gullberg, U, Lindmark, A, B├╝low, E, Olsson, I, Bengtsson, N, Garwicz, D

J Immunol Methods 1999
8329717 Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines

Ganz, T, Valore, EV, Oren, A, Liu, L

Blood 1993
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