HNP1-4 are released into phagocytic vacuoles

Stable Identifier
R-HSA-1462041
Type
Reaction [transition]
Species
Homo sapiens
Compartment
azurophil granule lumen, extracellular region
ReviewStatus
5/5
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HNP1-4 are released into phagocytic vacuoles
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Human neutrophils contain thousands of cytoplasmic granules. These membrane-bound organelles act as storage compartments destined for secretion or in the case of azurophil granules, destined for fusion with phagosomes. A small amount of defensin, but perhaps not enough for antimicrobial activity, may be released extracellularly by neutrophils (Ganz 1987).
Literature References
PubMed ID Title Journal Year
1302183 Defensins: endogenous antibiotic peptides from human leukocytes

Lehrer, RI, Ganz, T

Ciba Found Symp 1992
10618521 Processing and targeting of granule proteins in human neutrophils

Gullberg, U, Bengtsson, N, Bülow, E, Garwicz, D, Lindmark, A, Olsson, I

J Immunol Methods 1999
8329717 Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell lines

Ganz, T, Liu, L, Valore, EV, Oren, A

Blood 1993
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Orthologous Events
HNP1-4 are released into phagocytic vacuoles (Mus musculus)
HNP1-4 are released into phagocytic vacuoles (Rattus norvegicus)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)
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