Reactome | Pro-HNP1-4 are cleaved to biologically active defensin

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Pro-HNP1-4 are cleaved to biologically active defensin Show undefined attributes

authored	[InstanceEdit:1254178] Jupe, S, 2011-04-28
category	transition
compartment	[Compartment:17963] Golgi lumen
created	[InstanceEdit:1461974] Jupe, S, 2011-07-27
dbId	1462039
displayName	Pro-HNP1-4 are cleaved to biologically active defensin
edited	[InstanceEdit:1461956] Jupe, S, 2011-07-27
eventOf	[Pathway:R-HSA-1462054] Alpha-defensins - Homo sapiens
followingEvent	[Reaction:R-HSA-1462003] HNP1-4 are stored in primary neutrophil granules - Homo sapiens
input	[CandidateSet:R-HSA-1470043] Pro-defensins alpha 1-4 [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1462018] Posttranslational processing of defensins in immature human myeloid cells [LiteratureReference:1461967] Characterization of defensin precursors in mature human neutrophils
maxDepth	1
modified	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
name	Pro-HNP1-4 are cleaved to biologically active defensin
orthologousEvent	[Reaction:R-MMU-1462039] Pro-HNP1-4 are cleaved to biologically active defensin - Mus musculus [Reaction:R-RNO-1462039] Pro-HNP1-4 are cleaved to biologically active defensin - Rattus norvegicus
output	[CandidateSet:R-HSA-1470042] Defensins alpha 1-4 [Golgi lumen] [CandidateSet:R-HSA-8864968] Pro-defensin fragments [Golgi lumen]
precedingEvent	[BlackBoxEvent:R-HSA-1462023] Pre-pro-defensins are cleaved to remove the signal peptide - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1966942] McDermott, AM, 2011-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1462039
summation	[Summation:1461988] Synthesis of alpha defensins takes place in neutrophil precu...
updateTrackers	[UpdateTracker:9783202] Update Tracker - [Reaction:1462039] Pro-HNP1-4 are cleaved to biologically active defensin - v57:[addOutput]

Referrals

(updatedInstance)	[UpdateTracker:9783202] Update Tracker - [Reaction:1462039] Pro-HNP1-4 are cleaved to biologically active defensin - v57:[addOutput]
(hasEvent)	[Pathway:R-HSA-1462054] Alpha-defensins
(precedingEvent)	[Reaction:R-HSA-1462003] HNP1-4 are stored in primary neutrophil granules

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