Pro-HNP1-4 are cleaved to biologically active defensin

Stable Identifier
R-HSA-1462039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen
ReviewStatus
5/5
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Pro-HNP1-4 are cleaved to biologically active defensin
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Synthesis of alpha defensins takes place in neutrophil precursor cells, the promyelocytes, in the bone marrow. Pro HNP1-4 are cleaved in the Golgi body, with HNP-2 being derived from cleavage of the N-terminal amino acid from HNP-1 or HNP-3. The defensin propiece is not only important for correct sub-cellular trafficking and sorting but also inhibits HNP activity (Valore et al. 1996, Wu et al. 2007). The resulting mature peptides are sorted to primary neutrophil (azurophil) granules for storage (Valore & Ganz 1992, Harwig et al. 1992, Cowland & Borregaard).
Literature References
PubMed ID Title Journal Year
1547345 Characterization of defensin precursors in mature human neutrophils

Harwig, SS, Lehrer, RI, Park, AS

Blood 1992
1339298 Posttranslational processing of defensins in immature human myeloid cells

Ganz, T, Valore, EV

Blood 1992
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Orthologous Events
Pro-HNP1-4 are cleaved to biologically active defensin (Mus musculus)
Pro-HNP1-4 are cleaved to biologically active defensin (Rattus norvegicus)
Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-07-27)
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