Reactome | Interaction of other adapter proteins with p-KIT

Interaction of other adapter proteins with p-KIT

Stable Identifier

R-HSA-1433501

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Interaction of other adapter proteins with p-KIT

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Adapter proteins GADS, GRAP, GRB7 and GRB10 interact with activated KIT (Liu & McGlade 1998, Feng et al. 1996, Thömmes et al. 1999, Jahn et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8647802	Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway Ni, J, Ouyang, YB, Feng, GS, Gentz, R, Hu, DP, Shi, ZQ	J Biol Chem	1996
9872323	Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc Liu, SK, McGlade, CJ	Oncogene	1998
10377264	Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor Carlberg, M, Thömmes, K, Lennartsson, J, Rönnstrand, L	Biochem J	1999
11809791	Role for the adaptor protein Grb10 in the activation of Akt Jahn, T, Duyster, J, Urschel, S, Peschel, C, Seipel, P	Mol Cell Biol	2002
16129412	Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor Roskoski, R Jr	Biochem Biophys Res Commun	2005