Reactome | FASL:FAS Receptor Trimer:FADD complex binds procaspase-10

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FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:110071] Tschopp, J�rg, 2004-01-28
dbId	141310
displayName	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10
eventOf	[Pathway:R-HSA-75157] FasL/ CD95L signaling - Homo sapiens
figure	[Figure:141240] /figures/FasL_Fas_FADD_ProCaspase10.jpg
input	[EntityWithAccessionedSequence:R-HSA-933453] CASP10(1-521) [cytosol] [Complex:R-HSA-43124] FASL:FAS Receptor Trimer:FADD [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141306] Caspase-10 is an initiator caspase in death receptor signaling [LiteratureReference:141314] Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10
orthologousEvent	[Reaction:R-SSC-141310] FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 - Sus scrofa
output	[Complex:R-HSA-141315] FASL:FAS Receptor Trimer:FADD:pro-Caspase-10 [plasma membrane]
precedingEvent	[Reaction:R-HSA-83650] FasL:Fas binds FADD - Homo sapiens [BlackBoxEvent:R-HSA-6798139] TP53 stimulates CASP10 expression - Homo sapiens
releaseDate	2004-10-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-141310
summation	[Summation:178763] FADD recruits caspase-10 precursor (pro-caspase-10) to FASL:...
updateTrackers	[UpdateTracker:9785611] Update Tracker - [Reaction:141310] FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 - v51:[add_removeInput] [UpdateTracker:9788232] Update Tracker - [Reaction:141310] FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 - v43:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785611] Update Tracker - [Reaction:141310] FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 - v51:[add_removeInput] [UpdateTracker:9788232] Update Tracker - [Reaction:141310] FASL:FAS Receptor Trimer:FADD complex binds procaspase-10 - v43:[modifyText]
(hasEvent)	[Pathway:R-HSA-75157] FasL/ CD95L signaling

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