Reactome | FXN:ISD11:NFS1:ISCU [mitochondrial matrix]

Schema > Complex > Entries

FXN:ISD11:NFS1:ISCU [mitochondrial matrix] Show undefined attributes

catalystActivities	[CatalystActivity:9954151] ferrous iron binding activity of FXN:ISD11:NFS1:ISCU [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
consumedByEvent	[Reaction:R-HSA-1362416] Frataxin binds iron - Homo sapiens
created	[InstanceEdit:1362403] May, B, 2011-06-09
dbId	1362404
displayName	FXN:ISD11:NFS1:ISCU [mitochondrial matrix]
hasComponent	2 × [EntityWithAccessionedSequence:R-HSA-1362390] FXN(81-210) [mitochondrial matrix] 2 × [EntityWithAccessionedSequence:R-HSA-1362391] ISCU-1 [mitochondrial matrix] 2 × [EntityWithAccessionedSequence:R-HSA-1362392] LYRM4 [mitochondrial matrix] 2 × [EntityWithAccessionedSequence:R-HSA-1362396] PXLP-K258-NFS1-1 [mitochondrial matrix]
inDisease	false
inferredTo	[Complex:R-MMU-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Mus musculus [Complex:R-RNO-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Rattus norvegicus [Complex:R-CFA-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Canis familiaris [Complex:R-BTA-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Bos taurus [Complex:R-SSC-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Sus scrofa [Complex:R-DRE-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Danio rerio [Complex:R-XTR-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Xenopus tropicalis [Complex:R-GGA-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Gallus gallus [Complex:R-DME-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Drosophila melanogaster [Complex:R-CEL-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Caenorhabditis elegans [Complex:R-DDI-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Dictyostelium discoideum [Complex:R-SPO-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Schizosaccharomyces pombe [Complex:R-SCE-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Saccharomyces cerevisiae [Complex:R-PFA-1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - Plasmodium falciparum
isChimeric	false
literatureReference	[LiteratureReference:1362328] Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex [LiteratureReference:1362364] Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex [LiteratureReference:1362327] Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones [LiteratureReference:1362323] Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells
maxDepth	2
modified	[InstanceEdit:9644724] D'Eustachio, Peter, 2019-04-17
name	FXN:ISD11:NFS1:ISCU
producedByEvent	[Reaction:R-HSA-9866272] 2Fe-2S is inserted in UQCRFS1 - Homo sapiens [BlackBoxEvent:R-HSA-9854984] Transfer of Fe-S clusters to SDHB - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-1362404
updateTrackers	[UpdateTracker:9900538] Update Tracker - [Complex:1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - v69:[add_removeHasComponent]

Referrals

(updatedInstance)	[UpdateTracker:9900538] Update Tracker - [Complex:1362404] FXN:ISD11:NFS1:ISCU [mitochondrial matrix] - v69:[add_removeHasComponent]
(output)	[Reaction:R-HSA-9866272] 2Fe-2S is inserted in UQCRFS1 [BlackBoxEvent:R-HSA-9854984] Transfer of Fe-S clusters to SDHB
(input)	[Reaction:R-HSA-1362416] Frataxin binds iron
(physicalEntity)	[CatalystActivity:9954151] ferrous iron binding activity of FXN:ISD11:NFS1:ISCU [mitochondrial matrix]

© 2026 Reactome

Cite Us!