Reactome | FGFR4 binds HS:KLB:FGF19

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FGFR4 binds HS:KLB:FGF19 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1307956] Rothfels, K, 2011-05-30
dbId	1307955
displayName	FGFR4 binds HS:KLB:FGF19
eventOf	[Pathway:R-HSA-1307965] betaKlotho-mediated ligand binding - Homo sapiens
followingEvent	[Reaction:R-HSA-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-189888] FGF19 [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-189921] FGFR4 [plasma membrane] [SimpleEntity:R-ALL-190915] HS [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-1307932] KLB [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1307951] Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 [LiteratureReference:1307944] Relevant use of Klotho in FGF19 subfamily signaling system in vivo [LiteratureReference:1307940] Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members [LiteratureReference:1307949] The Klotho gene family as a regulator of endocrine fibroblast growth factors
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	FGFR4 binds HS:KLB:FGF19 FGFR4 binds BetaKlotho-bound FGF19
orthologousEvent	[Reaction:R-DME-1307955] FGFR4 binds HS:KLB:FGF19 - Drosophila melanogaster [Reaction:R-GGA-1307955] FGFR4 binds HS:KLB:FGF19 - Gallus gallus [Reaction:R-XTR-1307955] FGFR4 binds HS:KLB:FGF19 - Xenopus tropicalis [Reaction:R-DRE-1307955] FGFR4 binds HS:KLB:FGF19 - Danio rerio [Reaction:R-SSC-1307955] FGFR4 binds HS:KLB:FGF19 - Sus scrofa [Reaction:R-BTA-1307955] FGFR4 binds HS:KLB:FGF19 - Bos taurus [Reaction:R-CFA-1307955] FGFR4 binds HS:KLB:FGF19 - Canis familiaris [Reaction:R-RNO-1307955] FGFR4 binds HS:KLB:FGF19 - Rattus norvegicus [Reaction:R-MMU-1307955] FGFR4 binds HS:KLB:FGF19 - Mus musculus
output	[Complex:R-HSA-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
regulatedBy	[Requirement:R-HSA-1307970] Requirement by 'HS [extracellular region]'
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1307955
summation	[Summation:1384554] BetaKlotho (KLB) and heparan sulfate (HS) are required for f...
updateTrackers	[UpdateTracker:9789008] Update Tracker - [Reaction:1307955] FGFR4 binds HS:KLB:FGF19 - v39:[add_removeRegulator] [UpdateTracker:9786390] Update Tracker - [Reaction:1307955] FGFR4 binds HS:KLB:FGF19 - v49:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9789008] Update Tracker - [Reaction:1307955] FGFR4 binds HS:KLB:FGF19 - v39:[add_removeRegulator] [UpdateTracker:9786390] Update Tracker - [Reaction:1307955] FGFR4 binds HS:KLB:FGF19 - v49:[modifyText]
(hasEvent)	[Pathway:R-HSA-1307965] betaKlotho-mediated ligand binding
(precedingEvent)	[Reaction:R-HSA-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4

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