Reactome | FGFR4 binds HS:KLB:FGF19

Schema > Reaction > Entries

FGFR4 binds HS:KLB:FGF19 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10594940
displayName	FGFR4 binds HS:KLB:FGF19
eventOf	[Pathway:R-DRE-1307965] betaKlotho-mediated ligand binding - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 - Danio rerio
inferredFrom	[Reaction:R-HSA-1307955] FGFR4 binds HS:KLB:FGF19 - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-DRE-189888] fgf19 [extracellular region] 2 × [EntityWithAccessionedSequence:R-DRE-189921] FGFR4 [plasma membrane] [SimpleEntity:R-ALL-190915] HS [extracellular region] 2 × [EntityWithAccessionedSequence:R-DRE-1307932] klb [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FGFR4 binds HS:KLB:FGF19 FGFR4 binds BetaKlotho-bound FGF19
output	[Complex:R-DRE-1307953] FGFR4:HS:KLB:FGF19 [plasma membrane]
regulatedBy	[Requirement:R-HSA-190312] Requirement by 'HS [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1307955
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-1307965] betaKlotho-mediated ligand binding
(precedingEvent)	[Reaction:R-DRE-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4
(inferredTo)	[Reaction:R-HSA-1307955] FGFR4 binds HS:KLB:FGF19

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