PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1

Stable Identifier
R-HSA-1306979
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Active PI3K in complex with phosphorylated ERBB2:ERBB4cyt1 heterodimer phosphorylates PIP2 into PIP3, leading to activation of AKT signaling.

Literature References
PubMed ID Title Journal Year
10722704 A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis

Kainulainen, V, Sundvall, M, Määttä, JA, Santiestevan, E, Klagsbrun, M, Elenius, K

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created