SOS1 bound to GRB2 in complex with any of the phosphorylated ERBB2:ERBB4 heterodimers catalyzes guanyl-nucleotide exchange on RAS, leading to the activation of the MAP kinase cascade.
Sepp-Lorenzino, L, Eberhard, I, Ma, Z, Cho, C, Serve, H, Liu, F, Rosen, N, Lupu, R
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