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Schema
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Reaction
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Entries
Activation of HCN channels
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authored
[InstanceEdit:1296022] Mahajan, SS, 2011-05-18
catalystActivity
[CatalystActivity:1297433] monoatomic cation channel activity of HCNs:cAMP [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:1296042] Mahajan, SS, 2011-05-18
crossReference
[DatabaseIdentifier:12667477] RHEA:29463
dbId
1296043
displayName
Activation of HCN channels
edited
[InstanceEdit:1299511] Mahajan, SS, 2011-05-23
eventOf
[Pathway:R-HSA-1296061] HCN channels - Homo sapiens
input
[SimpleEntity:R-ALL-29804] K+ [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1296272] Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f)
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
Activation of HCN channels
orthologousEvent
[Reaction:R-DME-1296043] Activation of HCN channels - Drosophila melanogaster
[Reaction:R-GGA-1296043] Activation of HCN channels - Gallus gallus
[Reaction:R-XTR-1296043] Activation of HCN channels - Xenopus tropicalis
[Reaction:R-DRE-1296043] Activation of HCN channels - Danio rerio
[Reaction:R-SSC-1296043] Activation of HCN channels - Sus scrofa
[Reaction:R-BTA-1296043] Activation of HCN channels - Bos taurus
[Reaction:R-CFA-1296043] Activation of HCN channels - Canis familiaris
[Reaction:R-RNO-1296043] Activation of HCN channels - Rattus norvegicus
[Reaction:R-MMU-1296043] Activation of HCN channels - Mus musculus
output
[SimpleEntity:R-ALL-74126] K+ [extracellular region]
releaseDate
2011-06-14
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:975369] Jassal, Bijay, 2010-09-23
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1296043
summation
[Summation:1297441] HCN channels are activated upon hyperpolarization of membran...
Referrals
(hasEvent)
[Pathway:R-HSA-1296061] HCN channels
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