Reactome | Activation of HCN channels

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10594721] monoatomic cation channel activity of HCNs:cAMP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10594723
displayName	Activation of HCN channels
eventOf	[Pathway:R-DRE-1296061] HCN channels - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1296043] Activation of HCN channels - Homo sapiens
input	[SimpleEntity:R-ALL-29804] K+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of HCN channels
output	[SimpleEntity:R-ALL-74126] K+ [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-1296043
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-1296061] HCN channels
(inferredTo)	[Reaction:R-HSA-1296043] Activation of HCN channels

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