Activation of HCN channels

Stable Identifier
R-HSA-1296043
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of HCN channels
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HCN channels are activated upon hyperpolarization of membrane potential and cAMP binding leading to K+ efflux.

Literature References
PubMed ID Title Journal Year
11328811 Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f)

Moroni, A, Bianchi, ME, Gorza, L, Longhi, R, DiFrancesco, D, Beltrame, M, Altomare, C, Vitadello, M, Heurteaux, C, Malgaroli, A, Vaccari, T, Gravante, B

J Biol Chem 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cation channel activity of HCNs:cAMP [plasma membrane]

Physical Entity
HCNs:cAMP [plasma membrane] (Homo sapiens)
Activity
cation channel activity (GO:0005261)
Orthologous Events
Activation of HCN channels (Bos taurus)
Activation of HCN channels (Canis familiaris)
Activation of HCN channels (Danio rerio)
Activation of HCN channels (Drosophila melanogaster)
Activation of HCN channels (Gallus gallus)
Activation of HCN channels (Mus musculus)
Activation of HCN channels (Rattus norvegicus)
Activation of HCN channels (Sus scrofa)
Activation of HCN channels (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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