Activation of HCN channels

Stable Identifier
R-HSA-1296043
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HCN channels are activated upon hyperpolarization of membrane potential and cAMP binding leading to K+ efflux.

Literature References
PubMed ID Title Journal Year
11328811 Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f)

Moroni, A, Gorza, L, Beltrame, M, Gravante, B, Vaccari, T, Bianchi, ME, Altomare, C, Longhi, R, Heurteaux, C, Vitadello, M, Malgaroli, A, DiFrancesco, D

J Biol Chem 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cation channel activity of HCN channel bound to cAMP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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