PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3

Stable Identifier
R-HSA-1250462
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
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Activated PI3K complex directly bound to phosphorylated heterodimer of ERBB2 and ERBB3 phosphorylates PIP2 and converts it into PIP3, leading to activation of AKT signaling (Junttila et al. 2009).
Literature References
PubMed ID Title Journal Year
19411071 Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

Junttila, TT, Akita, RW, Parsons, K, Fields, C, Lewis Phillips, GD, Friedman, LS, Sampath, D, Sliwkowski, MX

Cancer Cell 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane]

Physical Entity
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Bos taurus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Caenorhabditis elegans)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Danio rerio)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Gallus gallus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Mus musculus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Sus scrofa)
Cross References
RHEA
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-21)
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