Reactome | Cross-presentation of soluble exogenous antigens (endosomes)

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Cross-presentation of soluble exogenous antigens (endosomes) Show undefined attributes

authored	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
created	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
dbId	1236978
displayName	Cross-presentation of soluble exogenous antigens (endosomes)
edited	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
eventOf	[Pathway:R-HSA-1236975] Antigen processing-Cross presentation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262909] antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1236939] Interaction of exogenous soluble antigen with its corresponding receptor - Homo sapiens [Reaction:R-HSA-1236941] Internalization of receptor bound antigen into clathrin coted vesicles - Homo sapiens [Reaction:R-HSA-1236955] Movement of clathrin coated vesicles into early endosome - Homo sapiens [Reaction:R-HSA-1236940] Exogenous soluble antigen targeted to more stable early endosome - Homo sapiens [BlackBoxEvent:R-HSA-1236968] Egress of internalized antigen into cytosol from early endosome - Homo sapiens [BlackBoxEvent:R-HSA-1236970] Proteasomal clevage of exogenous antigen (26S proteasome catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9912747] Proteasomal clevage of exogenous antigen (immunoproteasome catalyst) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2016-12-21
literatureReference	[LiteratureReference:1236647] Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells [LiteratureReference:1236557] Intracellular mechanisms of antigen cross presentation in dendritic cells [LiteratureReference:1236588] Cross-talk between the endocytic pathway and the endoplasmic reticulum in cross-presentation by MHC class I molecules
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Cross-presentation of soluble exogenous antigens (endosomes)
orthologousEvent	[Pathway:R-RNO-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Rattus norvegicus [Pathway:R-PFA-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Plasmodium falciparum [Pathway:R-SCE-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Saccharomyces cerevisiae [Pathway:R-SPO-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Schizosaccharomyces pombe [Pathway:R-DDI-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Dictyostelium discoideum [Pathway:R-CEL-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Caenorhabditis elegans [Pathway:R-DME-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Drosophila melanogaster [Pathway:R-GGA-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Gallus gallus [Pathway:R-XTR-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Xenopus tropicalis [Pathway:R-DRE-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Danio rerio [Pathway:R-SSC-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Sus scrofa [Pathway:R-BTA-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Bos taurus [Pathway:R-CFA-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Canis familiaris [Pathway:R-MMU-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295501] Desjardins, M, English, L, 2011-05-13 [InstanceEdit:9939491] Matthews, Lisa, 2025-02-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1236978
summation	[Summation:1236445] Exogenous soluble antigens are cross-presented by dendritic ...
updateTrackers	[UpdateTracker:9782569] Update Tracker - [Pathway:1236978] Cross-presentation of soluble exogenous antigens (endosomes) - v59:[updateContainedRLE] [UpdateTracker:9939782] Update Tracker - [Pathway:1236978] Cross-presentation of soluble exogenous antigens (endosomes) - v92:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9782569] Update Tracker - [Pathway:1236978] Cross-presentation of soluble exogenous antigens (endosomes) - v59:[updateContainedRLE] [UpdateTracker:9939782] Update Tracker - [Pathway:1236978] Cross-presentation of soluble exogenous antigens (endosomes) - v92:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-1236975] Antigen processing-Cross presentation

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