Reactome | Cross-presentation of soluble exogenous antigens (endosomes)

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Cross-presentation of soluble exogenous antigens (endosomes) Show undefined attributes

created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10827167
displayName	Cross-presentation of soluble exogenous antigens (endosomes)
eventOf	[Pathway:R-GGA-1236975] Antigen processing-Cross presentation - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262909] antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-1236941] Internalization of receptor bound antigen into clathrin coted vesicles - Gallus gallus [Reaction:R-GGA-1236955] Movement of clathrin coated vesicles into early endosome - Gallus gallus [Reaction:R-GGA-1236940] Exogenous soluble antigen targeted to more stable early endosome - Gallus gallus [BlackBoxEvent:R-GGA-1236970] Proteasomal clevage of exogenous antigen (26S proteasome catalyst) - Gallus gallus
inferredFrom	[Pathway:R-HSA-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Cross-presentation of soluble exogenous antigens (endosomes)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-1236978
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-1236975] Antigen processing-Cross presentation
(inferredTo)	[Pathway:R-HSA-1236978] Cross-presentation of soluble exogenous antigens (endosomes)

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