Reactome | Egress of internalized antigen into cytosol from early endosome

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Egress of internalized antigen into cytosol from early endosome Show undefined attributes

authored	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
category	omitted
compartment	[Compartment:171043] early endosome lumen [Compartment:70101] cytosol
created	[InstanceEdit:1236966] Garapati, P V, 2011-03-28
dbId	1236968
displayName	Egress of internalized antigen into cytosol from early endosome
edited	[InstanceEdit:1236976] Garapati, P V, 2011-03-28
eventOf	[Pathway:R-HSA-1236978] Cross-presentation of soluble exogenous antigens (endosomes) - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1236970] Proteasomal clevage of exogenous antigen (26S proteasome catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9912747] Proteasomal clevage of exogenous antigen (immunoproteasome catalyst) - Homo sapiens
input	[SimpleEntity:R-ALL-1236715] Exogenous soluble antigen [early endosome lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1236647] Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells [LiteratureReference:1236699] Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate [LiteratureReference:1236658] Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells [LiteratureReference:1236649] Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells [LiteratureReference:1236556] Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes [LiteratureReference:1236475] Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide [LiteratureReference:1236663] HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Egress of internalized antigen into cytosol from early endosome
output	[SimpleEntity:R-ALL-1236719] Exogenous soluble antigen [cytosol]
precedingEvent	[Reaction:R-HSA-1236940] Exogenous soluble antigen targeted to more stable early endosome - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1295501] Desjardins, M, English, L, 2011-05-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1236968
summation	[Summation:1236562] Endocytosed antigens must leave the endocytic structure to e...
updateTrackers	[UpdateTracker:9919495] Update Tracker - [BlackBoxEvent:1236968] Egress of internalized antigen into cytosol from early endosome - v90:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9919495] Update Tracker - [BlackBoxEvent:1236968] Egress of internalized antigen into cytosol from early endosome - v90:[modifyText]
(hasEvent)	[Pathway:R-HSA-1236978] Cross-presentation of soluble exogenous antigens (endosomes)
(precedingEvent)	[BlackBoxEvent:R-HSA-1236970] Proteasomal clevage of exogenous antigen (26S proteasome catalyst) [BlackBoxEvent:R-HSA-9912747] Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)