Reactome | ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol

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ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol Show undefined attributes

authored	[InstanceEdit:1234160] May, B, 2011-03-09
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:1234178] May, B, 2011-03-18
dbId	1234175
displayName	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
edited	[InstanceEdit:1234185] May, B, 2011-03-18
eventOf	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-1234159] Proteasome proteolyzes ub-HIF-alpha - Homo sapiens
input	[Complex:R-HSA-1234103] ub-HIF-alpha:VHL:EloB,C:CUL2:RBX1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1233955] Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein [LiteratureReference:1233961] Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein [LiteratureReference:8932467] Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
orthologousEvent	[BlackBoxEvent:R-MMU-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Mus musculus [BlackBoxEvent:R-CEL-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Caenorhabditis elegans [BlackBoxEvent:R-DME-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Drosophila melanogaster [BlackBoxEvent:R-GGA-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Gallus gallus [BlackBoxEvent:R-XTR-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Xenopus tropicalis [BlackBoxEvent:R-DRE-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Danio rerio [BlackBoxEvent:R-SSC-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Sus scrofa [BlackBoxEvent:R-BTA-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Bos taurus [BlackBoxEvent:R-CFA-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Canis familiaris [BlackBoxEvent:R-RNO-1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - Rattus norvegicus
output	[Complex:R-HSA-1234138] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol]
precedingEvent	[Reaction:R-HSA-1234172] Nuclear VBC complex ubiquitinylates HIF-alpha - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2255300] Rantanen, Krista, 2012-05-19
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-1234175
summation	[Summation:1235011] When hypoxic cells return to normoxia, HIF-alpha is ubiquiti...
updateTrackers	[UpdateTracker:9782700] Update Tracker - [BlackBoxEvent:1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - v58:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782700] Update Tracker - [BlackBoxEvent:1234175] ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol - v58:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-1234176] Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
(precedingEvent)	[BlackBoxEvent:R-HSA-1234159] Proteasome proteolyzes ub-HIF-alpha

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