ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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When hypoxic cells return to normoxia, HIF-alpha is ubiquitinated in the nucleus and exported to the cytosol (Groulx and Lee 2002). The shuttling of VHL between the nucleus and cytosol is required (Groulx and Lee 2002, Lee et al. 1999). Different cell types have different nucleocytoplasmic compartmentalization of HIF degradation (Zheng et al. 2006).

Literature References
PubMed ID Title Journal Year
16738327 Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization

Cao, Y, Salomons, FA, Ruas, JL, Poellinger, L, Pereira, T, Zheng, X, Cao, R

Mol. Cell. Biol. 2006
9891082 Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

Stearman, R, Pavlakis, GN, Stauber, R, Neumann, M, Klausner, RD, Lee, S, Pause, A

Mol Cell Biol 1999
12101228 Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

Lee, S, Groulx, I

Mol Cell Biol 2002
Orthologous Events
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