Reactome | EGFR E746_T751delinsA [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

EGFR E746_T751delinsA [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228032] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:1655493] COSMIC:COSM20845 [DatabaseIdentifier:1655490] COSMIC:COSV51769364 [DatabaseIdentifier:1655495] COSMIC:COSV51860456
dbId	1228031
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1248679] head and neck squamous cell carcinoma [Disease:1500689] cancer [Disease:1500699] lung cancer
displayName	EGFR E746_T751delinsA [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[FragmentReplacedModification:9626701] Replacement of residues 746 to 751 by A
inDisease	true
literatureReference	[LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
maxDepth	1
modified	[InstanceEdit:9626702] Orlic-Milacic, Marija, 2018-10-29
name	EGFR E746_T751delinsA Epidermal Growth Factor Receptor E746_T751delinsA EGFR Glu746_Thr751delinsAla EGFR E746_T751>A
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1228031
startCoordinate	25
updateTrackers	[UpdateTracker:9887632] Update Tracker - [EntityWithAccessionedSequence:1228031] EGFR E746_T751delinsA [plasma membrane] - v46:[modifyName] [UpdateTracker:9899768] Update Tracker - [EntityWithAccessionedSequence:1228031] EGFR E746_T751delinsA [plasma membrane] - v67:[add_removeHasModifiedResidue]

Referrals

(updatedInstance)	[UpdateTracker:9887632] Update Tracker - [EntityWithAccessionedSequence:1228031] EGFR E746_T751delinsA [plasma membrane] - v46:[modifyName] [UpdateTracker:9899768] Update Tracker - [EntityWithAccessionedSequence:1228031] EGFR E746_T751delinsA [plasma membrane] - v67:[add_removeHasModifiedResidue]
(hasCandidate)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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