Reactome | EGFR E746_S752delinsV [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

EGFR E746_S752delinsV [plasma membrane] Show undefined attributes

candidateOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228023] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:1655501] COSMIC:COSM18492 [DatabaseIdentifier:1655500] COSMIC:COSV51769675 [DatabaseIdentifier:1655497] COSMIC:COSV51765862 [DatabaseIdentifier:1655491] COSMIC:COSV51765862
dbId	1228025
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500689] cancer [Disease:1500699] lung cancer
displayName	EGFR E746_S752delinsV [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[FragmentReplacedModification:9626697] Replacement of residues 746 to 752 by V
inDisease	true
literatureReference	[LiteratureReference:1228027] EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
maxDepth	1
modified	[InstanceEdit:9628417] Orlic-Milacic, Marija, 2018-11-08
name	EGFR E746_S752delinsV Epidermal Growth Factor Receptor E746_S752delinsV EGFR Glu746_Ser752delinsVal EGFR E746_S752>V
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1228025
startCoordinate	25
updateTrackers	[UpdateTracker:9888449] Update Tracker - [EntityWithAccessionedSequence:1228025] EGFR E746_S752delinsV [plasma membrane] - v46:[modifyName] [UpdateTracker:9899833] Update Tracker - [EntityWithAccessionedSequence:1228025] EGFR E746_S752delinsV [plasma membrane] - v67:[add_removeHasModifiedResidue]

Referrals

(updatedInstance)	[UpdateTracker:9888449] Update Tracker - [EntityWithAccessionedSequence:1228025] EGFR E746_S752delinsV [plasma membrane] - v46:[modifyName] [UpdateTracker:9899833] Update Tracker - [EntityWithAccessionedSequence:1228025] EGFR E746_S752delinsV [plasma membrane] - v67:[add_removeHasModifiedResidue]
(hasCandidate)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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