Reactome | EGFR L747_P753delinsS [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

EGFR L747_P753delinsS [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1228006] Orlic-Milacic, Marija, 2011-03-16
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233 [DatabaseIdentifier:1655492] COSMIC:COSM13564 [DatabaseIdentifier:1655498] COSMIC:COSV51767961
dbId	1228010
disease	[Disease:1247848] non-small cell lung carcinoma [Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:1655499] prostate cancer [Disease:1655494] prostate adenocarcinoma
displayName	EGFR L747_P753delinsS [plasma membrane]
endCoordinate	1210
hasModifiedResidue	[FragmentReplacedModification:9628403] Replacement of residues 747 to 753 by S
inDisease	true
literatureReference	[LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
maxDepth	1
memberOf	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9628405] Orlic-Milacic, Marija, 2018-11-08
name	EGFR L747_P753delinsS Epidermal Growth Factor Receptor L747_P753delinsS EGFR Leu747_Pro753delinsSer EGFR L747_P753>S
referenceEntity	[ReferenceGeneProduct:uniprot:P00533] UniProt:P00533 EGFR
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-1228010
startCoordinate	25
updateTrackers	[UpdateTracker:9899820] Update Tracker - [EntityWithAccessionedSequence:1228010] EGFR L747_P753delinsS [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9887799] Update Tracker - [EntityWithAccessionedSequence:1228010] EGFR L747_P753delinsS [plasma membrane] - v46:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9899820] Update Tracker - [EntityWithAccessionedSequence:1228010] EGFR L747_P753delinsS [plasma membrane] - v67:[add_removeHasModifiedResidue] [UpdateTracker:9887799] Update Tracker - [EntityWithAccessionedSequence:1228010] EGFR L747_P753delinsS [plasma membrane] - v46:[modifyName]
(hasMember)	[CandidateSet:R-HSA-1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]

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