Reactome | Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL

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Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL Show undefined attributes

authored	[InstanceEdit:1181143] May, B, 2011-01-23
catalystActivity	[CatalystActivity:1225901] protein serine/threonine kinase activity of NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1225868] May, B, 2011-03-03
dbId	1225894
displayName	Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL
edited	[InstanceEdit:1181143] May, B, 2011-01-23
eventOf	[Pathway:R-HSA-1181150] Signaling by NODAL - Homo sapiens
followingEvent	[Reaction:R-HSA-1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor - Homo sapiens
inferredFrom	[Reaction:R-HSA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin - Homo sapiens
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-1225912] NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:1181296] ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse [LiteratureReference:1181094] The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development [LiteratureReference:1549506] Nodal and activin receptor-like kinase 7 induce apoptosis in human breast cancer cell lines: Role of caspase 3 [LiteratureReference:1225998] Nodal Signals through Activin Receptor-Like Kinase 7 to Inhibit Trophoblast Migration and Invasion Implication in the Pathogenesis of Preeclampsia
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL
output	10 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-1225915] NODAL:p-ACVR1C:ACVR2B:EGF-CFC [plasma membrane]
precedingEvent	[Reaction:R-HSA-1181155] The NODAL Receptor binds NODAL ligands - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1529118] Peng, C, 2011-08-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1225894
summation	[Summation:1225997] As inferred from the response of the activin receptor to act...

Referrals

(hasEvent)	[Pathway:R-HSA-1181150] Signaling by NODAL
(precedingEvent)	[Reaction:R-HSA-1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor
(inferredTo)	[Reaction:R-HSA-1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

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